Table 1.
Characteristics of the subjects and frequency of genotypes
| Total | non CIHM | CIHM | p value* | |
|---|---|---|---|---|
| number of subjects |
401 |
153 |
248 |
|
| mean age ± SD |
60.0 ± 13.8 |
60.2 ± 13.7 |
59.9 ± 13.9 |
NS |
| male : female |
230 : 171 |
87 : 66 |
143 : 105 |
NS |
|
H. pylori positive rate |
241/401 |
71/153 |
170/248 |
<0.0001 |
| -197 G > A |
|
|
|
|
| GG |
155 |
65 |
90 |
|
| GA |
204 |
74 |
130 |
|
| AA |
41 |
14 |
27 |
|
| (unknown) |
1 |
0 |
1 |
|
| A allele frequency |
35.8% |
33.3% |
37.2% |
NS |
| *1249 C > T |
|
|
|
|
| CC |
340 |
124 |
216 |
0.058a |
| CT |
42 |
20 |
22 |
|
| TT |
16 |
9 |
7 |
|
| (unknown) |
3 |
0 |
3 |
|
| T allele frequency | 9.3% | 12.4% | 7.3% | 0.023 |
non CIHM: neither DAPK nor CDH1 were methylated.
CIHM: both or either DAPK or CDH1was methyaled.
*: unmethylated vs. methylated.
a: frequency of *1249 CC genotype.