Table 6.
Risk of rs2275913 and rs3748067 for gene methylations
| CIHM (DAPKorCDH1) | |||||
|---|---|---|---|---|---|
| over all |
HR |
LR |
unknown |
HR vs. LR; OR (95%CI) |
p value |
| unmethylated (153) |
76 |
77 |
0 |
reference |
- |
| methylated (248) |
144 |
101 |
3 |
1.45 (0.955-2.20) |
0.081 |
| 60 = < |
|
|
|
|
|
| unmethylated (83) |
38 |
45 |
0 |
reference |
- |
| methylated (143) |
89 |
54 |
0 |
1.93 (1.10-3.39) |
0.023 |
|
DAPK |
|
|
|
|
|
| over all |
HR |
LR |
unknown |
HR vs. LR; OR (95%CI) |
p value |
| unmethylated (205) |
102 |
102 |
1 |
reference |
- |
| methylated (196) |
118 |
76 |
2 |
1.57 (1.04-2.35) |
0.031 |
| 60 = < |
|
|
|
|
|
| unmethylated (103) |
49 |
54 |
0 |
reference |
- |
| methylated (123) |
78 |
45 |
0 |
1.91 (1.10-3.30) |
0.021 |
|
CDH1 |
|
|
|
|
|
| over all |
HR |
LR |
unknown |
HR vs. LR; OR (95%CI) |
p value |
| unmethylated (252) |
134 |
116 |
2 |
reference |
- |
| methylated (149) |
86 |
62 |
1 |
1.20 (0.787-1.83) |
0.40 |
| 60 = < |
|
|
|
|
|
| unmethylated (145) |
73 |
72 |
0 |
reference |
- |
| methylated (81) |
54 |
27 |
0 |
2.01 (1.12-3.62) |
0.020 |
|
DAPK and CDH1 |
|
|
|
|
|
| over all |
HR |
LR |
unknown |
HR vs. LR; OR (95%CI) |
p value |
| unmethylated (304) |
160 |
141 |
3 |
reference |
- |
| methylated (97) |
60 |
37 |
0 |
1.44 (0.890-2.34) |
0.14 |
| 60 = < |
|
|
|
|
|
| unmethylated (165) |
84 |
81 |
0 |
reference |
- |
| methylated (61) | 43 | 18 | 0 | 2.42 (1.25-4.68) | 0.0087 |
HR: -197 A carrier with*1249 CC genotype, LR: the others by logistic regression analysis after adjustment for age, gender and H. pylori infection status.
( ): number of subjects.