Table 2.
Survival of SC-19 and ΔperR in different organs in mice
| Source | Strain |
Bacteria recovered from blood and tissues (×105 CFU)a |
||
|---|---|---|---|---|
| 4 dpi | 7 dpib | 11 dpib | ||
| Blood |
SC-19 |
4.49 ± 3.24 |
2.37 ± 1.71 |
0.44 ± 0.04 |
| |
ΔperR |
4.10 ± 2.41 |
0.09 ± 0.05 |
0 |
| Lung |
SC-19 |
4.22 ± 1.45 |
1.48 ± 0.11 |
1.03 ± 1.59 |
| |
ΔperR |
1.66 ± 1.11 |
0.07 ± 0.04 |
0 |
| Brain |
SC-19 |
5.07 ± 3.07 |
1.42 ± 0.20 |
1.62 ± 1.33 |
| |
ΔperR |
3.84 ± 2.96 |
0.13 ± 0.12 |
0.01 ± 0.01 |
| Spleen |
SC-19 |
0.15 ± 0.09 |
0.35 ± 0.11 |
0.03 ± 0.02 |
| ΔperR | 0.22 ± 0.22 | 0.04 ± 0.04 | 0 | |
a Mean ± standard deviation of 4 independent experiments. Date is expressed as CFU/ml blood, or CFU per tissue.
bP<0.05 for comparison of SC-19 versus ΔperR CFU at 7 and 11 dpi (student’s t-test).