Table 5.
Significant (Uncorrected) Analyses of SNPs Previously Reported as NTD Risk Factors in this Population
| Gene/SNP | MAF* | Cohort** | Model | OR | 95% CI (LL) | 95% CI (UL) | P |
|---|---|---|---|---|---|---|---|
|
MTHFR rs1801133 677 C > T |
0.32 |
Combined |
LR CC Continuous |
1.23 |
1.05 |
1.45 |
0.011 |
| |
|
Combined |
LR CC Recessive |
1.26 |
1.01 |
1.57 |
0.041 |
| |
|
Combined |
LR CC Dominant |
1.44 |
1.04 |
2.00 |
0.029 |
| |
|
Combined |
LR MC Continuous |
1.22 |
1.04 |
1.43 |
0.017 |
| |
|
Combined |
LR MC Recessive |
1.25 |
1.01 |
1.57 |
0.045 |
| |
|
|
|
|
|
|
|
|
MTHFD1 rs2236225 R653Q |
0.46 |
Primary |
LR MC Continuous |
1.35 |
1.06 |
1.71 |
0.014 |
| |
|
Primary |
LR MC Dominant |
1.97 |
1.28 |
3.04 |
0.002 |
| |
|
Combined |
LR MC Dominant |
1.48 |
1.14 |
1.92 |
0.003 |
| |
|
Primary |
LL Case effect, dominant |
0.53 |
0.30 |
0.93 |
0.026 |
| |
|
Combined |
LL TDT |
0.80 |
0.65 |
0.99 |
0.039 |
| |
|
Combined |
LL Case effect, dominant |
0.60 |
0.42 |
0.86 |
0.005 |
| TCblR rs2336573 G220R | 0.04 | Combined | LR CC Dominant | .*** | 0.013 |
*For each SNP, the minor allele was evaluated as the risk allele.
** Primary: 320 triads, 341 controls. Combined: 570 triads, 999 controls.
*** (.) = Failure to converge. Pexact is shown.