Figure 8. A working model for KCC in the regulation of bactericidal activity.

In the resting status of neutrophil, KCC (at least KCC3) and the membrane components of NADPH oxidase are diffusely expressed. In activated neutrophil, NADPH oxidase complexes are associated with KCC3 at the plasma membrane and are internalized to form phagosomes, where KCC activity and expression level affect the production of oxidants. The KCC family might be one of the Cl⁻ permeation pathways providing the substrate for the generation of OCl⁻ in phagosomes.