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. 2012 May 8;590(Pt 14):3305–3316. doi: 10.1113/jphysiol.2012.229690

Figure 2. Autophagy is impaired in the vasculature of old mice and restored by trehalose supplementation.

Figure 2

A, key autophagy mediator beclin 1 in aorta of young and old control (YC and OC) and young and old trehalose supplemented (YTre and OTre) mice. B, p62, a marker of undegraded autophagy substrates. C and D, WIPI-1 and LC3-II, markers/indexes of macroautophagy. E, LAMP-2a, critical mediator of chaperone-mediated autophagy. Data expressed relative to GAPDH and normalized to YC mean value. Representative Western blot images below. Values are means ± SEM (n= 5–7 per group). *P < 0.05 vs. YC.