Table 1.

Acute and chronic effects of CBD on arterial blood gases

Strain	Condition	pH	HCO3−
Pre-CBD
BN (n= 7)	RA	7.484 ± 0.006	23.2 ± 0.3	32.0 ± 0.8	84.1 ± 1.6
	7% CO2	7.355 ± 0.008	24.9 ± 1.0	46.2 ± 1.9	113.0 ± 2.4
SS (n= 7)	RA	7.498 ± 0.007 #	23.8 ± 0.2	31.7 ± 0.4	86.7 ± 1.9
	7% CO2	7.379 ± 0.006 #	25.3 ± 0.4	44.3 ± 0.8	114.2 ± 2.4
SD (n= 6)	RA	7.474 ± 0.005	23.7 ± 1.0	33.4 ± 1.5	87.1 ± 1.8
	7% CO2	7.352 ± 0.010	26.5 ± 1.6	49.6 ± 3.1 #	128.3 ± 3.9 #
1–4 days post-CBD
BN (n= 7)	RA	7.484 ± 0.007	28.5 ± 0.7*	40.7 ± 0.8*	71.9 ± 2.0*
	7% CO2	7.376 ± 0.010*	28.9 ± 0.5*	51.0 ± 0.6*	109.3 ± 1.5
SS (n= 7)	RA	7.478 ± 0.010*	30.4 ± 0.9*	42.4 ± 1.0*	68.4 ± 3.5*
	7% CO2	7.401 ± 0.007*#	30.5 ± 0.4*	50.9 ± 0.6*	110.9 ± 2.1
SD (n= 6)	RA	7.454 ± 0.008	27.9 ± 0.9	41.1 ± 1.2*	69.6 ± 3.0*
	7% CO2	7.367 ± 0.010*	28.5 ± 0.7	51.2 ± 0.8	113.3 ± 3.5*
>10 days post-CBD
BN (n= 7)	RA	7.500 ± 0.007	22.9 ± 0.4	31.1 ± 0.9	85.8 ± 3.2
	7% CO2	7.350 ± 0.007	25.2 ± 0.3	47.4 ± 1.2	115.1 ± 4.7
SS (n= 7)	RA	7.479 ± 0.010*	24.8 ± 1.0	34.5 ± 1.3*	76.9 ± 2.4*
	7% CO2	7.391 ± 0.007 #	25.1 ± 0.6	42.9 ± 0.9	108.5 ± 1.2
SD (n= 6)	RA	7.471 ± 0.009	24.3 ± 0.7	34.6 ± 1.6	79.3 ± 3.0*
	7% CO2	7.351 ± 0.003	26.5 ± 0.7	49.6 ± 1.2	116.5 ± 3.7*

^*Significantly different from pre-CBD (P < 0.05)

^#significant difference among strains within time point (P < 0.05) by 2-way RM ANOVA.