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. 2012 Aug 22;32(34):11716–11726. doi: 10.1523/JNEUROSCI.1942-12.2012

Figure 10.

Figure 10.

BRAG1 signaling regulates synaptic trafficking of GluA1-containing AMPA-Rs. A, Evoked AMPA-R-mediated (−60 mV) and NMDA-R-mediated (+40 mV) responses recorded from neighboring nonexpressing (Ctrl) and mCherry-tagged BRAG1-IQ or BRAG1-ΔN expressing neurons prepared from GluA1 or GluA2 knock-out mice. B, Values for AMPA responses in BRAG1-IQ and BRAG1-ΔN expressing neurons prepared from GluA1 (Ctrl: −23.5 ± 1.8 pA; IQ: −24.1 ± 2.0 pA; n = 20, p = 0.88; Ctrl: −26.2 ± 2.5 pA; ΔN: −26.2 ± 1.5 pA; n = 20, p = 0.82) or GluA2 (Ctrl: −30.9 ± 2.1 pA; IQ: −20.9 ± 1.6 pA; n = 20, p < 0.005; Ctrl: −24.5 ± 1.7 pA; ΔN: −31.5 ± 2.9 pA; n = 24, p < 0.005) knock-out mice, and for NMDA responses in BRAG1-IQ and BRAG1-ΔN expressing neurons prepared from GluA1 (Ctrl: 94.9 ± 7.6 pA; IQ: 91.9 ± 8.4 pA; n = 20, p = 0.91; Ctrl: 113.6 ± 8.7 pA; ΔN: 111.9 ± 9.8 pA; n = 20, p = 0.97) or GluA2 (Ctrl: 54.5 ± 5.0 pA; IQ: 54.8 ± 5.2 pA; n = 20, p = 0.46; Ctrl: 60.1 ± 5.2 pA; ΔN: 61.8 ± 4.4 pA; n = 24, p = 0.63) knock-out mice. The relative values and SEs were normalized to average amounts of AMPA and NMDA responses from control CA1 cells. *p < 0.05 (Wilcoxon test).