Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Model for BRAG1-mediated synaptic trafficking of GluA1-containing AMPA-Rs. BRAG1 is anchored at PSDs via its interaction with PSD-95, which also interacts with NMDA receptors. Calcium influx triggered by NMDAR activation causes CaM release from BRAG1, which causes a conformational change leading to enhanced catalytic activity. BRAG1 activates Arf6 which, through downstream activation of JNK, triggers internalization of GluA1-containing AMPA receptors.
