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. Author manuscript; available in PMC: 2013 Feb 8.
Published in final edited form as: Structure. 2012 Jun 21;20(8):1374–1383. doi: 10.1016/j.str.2012.05.009

Figure 2.

Figure 2

Multiple crystal forms display interlocked α4β4 rings for E. coli RNR. Each α4β4 ring is colored separately with F2CDP/ATP-RNR complex in blue/yellow and dATP-RNR complex in green/purple. (A,B) One asymmetric unit for each complex is shown as ribbons with transparent surface and with full surface, for F2CDP/ATP- and dATP-RNR complexes, respectively. (C,D) The full (α4β4)2 RNR complex is shown from front and side orientations for each complex. (E,F) A top down view of each RNR complex shows the packing of two α2-dimers (left) and close-up of interactions of just the α2 dimers in an identical orientation (right). Other known structures with interlocked rings are shown in Fig. S3.