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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Gastroenterology. 2012 Jun 12;143(4):1061–1072. doi: 10.1053/j.gastro.2012.06.003

Figure 7. High-DC immunogenicity is abrogated by blocking TNF-α or lessening ER stress.

Figure 7

(a) CD4+OT-II T cells were cultured alone or co-cultured with High- or Low-DC.Ova323-339 in the presence or absence of an mAb against TNF-α. IFN-γ was measured in cell culture supernatant. (b, c) Similarly, DC-NK co-cultures were performed in the presence of TNF-α blockade before measuring (b) IFN-γ and (c) IL-6. (d) Peptide-pulsed High-DC, alone or with chaperone, were used to stimulate OT-II T cells. TNF-α was measured in cell culture supernatant. Experiments were repeated 2–3 times (*P<0.05; **P<0.01; ***P<0.001).