Heligmosomoides polygyrus
|
Chonic human intestinal nematode infections |
Proximal small intestine, transiently tissue penetrating (L4), adults reside in lumen |
++, highly polarized |
Chronic infection in most mouse strains for weeks/months |
Trichuris muris
|
Human whipworm infections |
Caecum and upper colon, intraepithelial with distal end in lumen |
+/++, strongly dependent on mouse strain |
Depends on infective dose and mouse strain, mostly expelled within 3 weeks |
Trichinella spiralis
|
Infective to broad spectrum of mammals |
Intraepithelial in small intestine, newborn infective larvae migrate into muscle tissue |
++ |
Rodents expel adults within 2 weeks; long survival of infective L3 in muscle tissue |