Table 2.

Adjusted^* hazard ratios (HR) and 95% confidence intervals (CI) of incident coronary heart disease according to 9p21 genotype, stratified by baseline risk factors, ARIC, 1987-2008^‡

		9p21 rs10757274
		AA	AG vs AA		GG vs AA		Per G Allele		p-interaction†
Risk Factor	Stratum	HR	HR	95% CI	HR	95% CI		95% CI
Age*	45-54 y	1.00	1.33	1.10-1.61	1.53	1.24-1.89	1.23	1.11-1.36	0.44
	55-64 y	1.00	1.21	1.03-1.42	1.36	1.13-1.63	1.17	1.07-1.27
Sex*	Men	1.00	1.29	1.04-1.59	1.32	1.04-1.68	1.15	1.02-1.29	0.41
	Women	1.00	1.23	1.06-1.42	1.45	1.22-1.72	1.22	1.12-1.32
Diabetes*	Yes	1.00	1.24	0.93-1.65	1.48	1.07-2.05	1.24	1.06-1.46	0.59
	No	1.00	1.27	1.11-1.45	1.41	1.21-1.64	1.18	1.10-1.27
Obesity*	Yes	1.00	1.13	0.91-1.41	1.24	0.96-1.60	1.11	0.98-1.27	0.22
	No	1.00	1.32	1.14-1.53	1.52	1.29-1.79	1.22	1.13-1.33
Current smoker*	Yes	1.00	1.23	0.99-1.52	1.22	0.95-1.57	1.10	0.98-1.25	0.14
	No	1.00	1.28	1.10-1.48	1.54	1.31-1.82	1.23	1.14-1.34
Hypertension*	Yes	1.00	1.30	1.07-1.58	1.52	1.22-1.90	1.25	1.19-1.39	0.31
	No	1.00	1.23	1.05-1.43	1.35	1.13-1.61	1.16	1.06-1.26
Hypercholesterolemia*	Yes	1.00	1.29	1.12-1.49	1.36	1.16-1.60	1.16	1.08-1.26	0.24
	No	1.00	1.16	0.91-1.48	1.60	1.23-2.08	1.28	1.12-1.45
10-yr CHD risk ≥ 5%	Yes	1.00	1.22	1.03-1.45	1.37	1.13-1.67	1.17	1.07-1.29	0.86
	No	1.00	1.23	1.03-1.46	1.42	1.17-1.72	1.19	1.08-1.31
Carotid IMT ≥ 75%ile*	Yes	1.00	1.35	1.11-1.64	1.18	0.94-1.49	1.09	0.98-1.21	0.04
	No	1.00	1.21	1.03-1.42	1.60	1.35-1.91	1.27	1.16-1.38
Carotid plaque*	Yes	1.00	1.29	1.09-1.53	1.38	1.13-1.67	1.17	1.06-1.29	0.57
	No	1.00	1.23	1.03-1.47	1.50	1.23-1.82	1.22	1.10-1.34

^*Adjusted for the other risk factors in the table and gender, but not for 10-year CHD risk.

^†P-value for difference in 9p21 association (per G allele) between risk factor strata.

^‡Based on 1653 CHD events over 17.4 years of follow-up.