Table 3.

Adjusted^* hazard ratios (RR) and 95% confidence intervals (CI) of incident coronary heart disease according to 9p21 genotype, stratified by risk biomarkers, ARIC^‡

		9p21 rs10757274
		AA	AG vs AA		GG vs AA		Per G Allele		p-interaction†
Risk Factor	Stratum	HR	HR	95% CI	HR	95% CI	HR	95% CI
HbA1c ≥ 75%ile	Yes	1.00	1.13	0.93-1.37	1.34	1.07-1.67	1.16	1.04-1.30	0.70
	No	1.00	1.24	1.03-1.48	1.45	1.19-1.78	1.20	1.08-1.32
C-reactive protein ≥ 75%ile	Yes	1.00	1.06	0.78-1.45	1.06	0.74-1.51	1.03	0.86-1.23	0.17
	No	1.00	1.29	1.04-1.60	1.45	1.14-1.84	1.20	1.06-1.35
Troponin T ≥ 75%ile	Yes	1.00	1.14	0.88-1.47	1.32	0.99-1.77	1.14	0.99-1.32	0.94
	No	1.00	1.28	1.00-1.63	1.35	1.02-1.77	1.15	1.01-1.32
NT-proBNP ≥ 75%ile	Yes	1.00	1.06	0.78-1.45	1.26	0.88-1.80	1.11	0.93-1.33	0.70
	No	1.00	1.26	1.01-1.56	1.36	1.06-1.73	1.16	1.03-1.31
Lp-PLA2 ≥ 75%ile	Yes	1.00	1.44	1.08-1.91	1.47	1.05-2.06	1.22	1.04-1.43	0.35
	No	1.00	1.05	0.84-1.32	1.23	0.96-1.58	1.11	0.98-1.26
Cystatin C ≥ 75%ile	Yes	1.00	1.14	0.85-1.52	1.09	0.78-1.53	1.04	0.88-1.23	0.19
	No	1.00	1.24	1.00-1.55	1.44	1.13-1.85	1.20	1.06-1.36

^*Adjusted for other baseline risk factors (Table 2) except carotid IMT. HbA1c is not adjusted for diabetes.

^†P-value for difference in 9p21 association (per G allele) between risk factor strata.

^‡RRs for HbA1c based on 1393 CHD events over 15.0 years of follow-up; other RRs based on 786 CHD events over 10.2 years of follow-up.