Table 1.

Five-year second primary malignancy rates after index oropharyngeal cancer for HPV-seronegative and HPV-seropositive patients segregated by demographic variables.

Variable	Patients,	HPV negative	HPV positive	Log-rank
		(N=102)	(N=80)
		5-yr SPM rate, %	5-yr SPM rate, %
	No.	(95% CI)	(95% CI)	p value
Total	182	14.6 (8.6–24.4)	5.6 (2.1–14.3)	0.051
Age
≤55 years	99	8.1 (2.7–23.2)	2.0 (0.3–13.4)	0.059
> 55 years	83	20.6 (11.2–35.9)	13.7 (4.5–37.6)	0.517
Sex
Male	150	10.6 (5.2–21.1)	4.8 (1.6–14.4)	0.057
Female	32	29.6 (13.4–57.4)	11.1 (1.6–56.7)	0.722
Race
Non-Hispanic white	163	13.9 (7.7–24.3)	5.8 (2.2–14.7)	0.052
Other	19	19.2 (5.0–59.0)	0.0	0.488
Smoking
Never	65	17.6 (7.7–37.4)	0.0	0.018
Ever	117	13.2 (6.5–25.9)	10.5 (4.0–26.1)	0.657
Alcohol use
Never	35	26.6 (10.8–56.5)	5.9 (0.1–35.0)	0.487
Ever	147	12.0 (6.2–22.7)	5.4 (1.7–16.0)	0.056
Comorbidities
None or mild	173	13.7 (7.8–23.4)	4.5 (1.5–13.4)	0.043
Moderate or severe	9	0.0	25.0 (4.0–87.2)	0.937

Abbreviations: CI, confidence interval; HPV, human papillomavirus; SPM, second primary malignancy.