Table 4.
Sites of second primary malignancies after index oropharyngeal cancer segregated by HPV serologic status and smoking status.
| Site | HPV−
|
HPV+ ever smokers
|
HPV+ never smokers
|
|||
|---|---|---|---|---|---|---|
| No. | (%) | No. | (%) | No. | (%) | |
| Total second primary malignancies | 24 | (100) | 7 | (100) | 3 | (100) |
| Head and neck | 5 | (20.8) | 1 | (14.3) | 0 | (0.0) |
|
|
|
|
|
|||
| Oral cavity | 1 | 1 | 0 | |||
| Oropharynx | 1 | 0 | 0 | |||
| Larynx | 2 | 0 | 0 | |||
| Hypopharynx | 1 | 0 | 0 | |||
| Tobacco related | 10 | (41.7) | 1 | (14.3) | 1 | (33.3) |
|
|
|
|
|
|||
| Lung and bronchus | 8 | 1 | 1 | |||
| Esophagus | 1 | 0 | 0 | |||
| Urinary bladder | 1 | 0 | 0 | |||
| Others | 9 | (37.5) | 5 | (71.4) | 2 | (66.7) |
|
|
|
|
|
|||
| Prostate | 3 | 1 | 1 | |||
| Kidney | 1 | 1 | 0 | |||
| Breast | 1 | 0 | 0 | |||
| Colon | 0 | 1 | 0 | |||
| Thyroid | 0 | 0 | 1 | |||
| Liver | 1 | 0 | 0 | |||
| Endometrium | 0 | 1 | 0 | |||
| Appendix | 1 | 0 | 0 | |||
| AML | 1 | 0 | 0 | |||
| Soft tissue | 1 | 0 | 0 | |||
| Unknown | 0 | 1 | 0 | |||
Abbreviations: HPV, human papillomavirus; HPV+, HPV positive; HPV−, HPV negative; AML, acute myeloid leukemia