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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Heart Rhythm. 2012 Jun 19;9(10):1698–1705. doi: 10.1016/j.hrthm.2012.06.031

Figure 4. Computer simulations showing that the gain of Ca-to-Vm coupling changed from negative to positive as pacing rate increased.

Figure 4

In control alternans occurred when pacing rate reached 180 bpm or faster. Ca-to-Vm coupling was positive. Inhibiting INCX (by 80%) Ca-to-Vm coupling was negative at pacing rate between 220 and 290 bpm. As pacing rate increased to >300 bpm, Ca-to-Vm coupling changed to positive.