Table 1.

Regulatory proteins affecting icaADBC expression in staphylococci.

Regulatory factor	Overall effect on icaADBC transcription	Probable mechanism	Reference
Sa IcaR	Negative	Direct binding to icaADBC promoter	Conlon et al. (2002)
Se IcaR			Jefferson et al. (2003)
Sa SarA	Positive	Direct binding to icaADBC promoter	Valle et al. (2003)
Se SarA			Tormo et al. (2005)
Se SarX	Positive	Direct binding to icaADBC promoter	Rowe et al. (2010)
Se SarZ	Positive	Unknown	Wang et al. (2008)
Sa TcaR	Negative	Direct binding to icaADBC promoter	Jefferson et al. (2004)
Se TcaR			Chang et al. (2010)
Sa σB	Variable depending on study	Indirect	See text
Se σB
Sa Rbf	Positive	Repression of icaR through a hypothetical regulator	Cue et al. (2009)
Se Rbf			Rowe (2010)
Se LuxS	Negative	Unknown	Xu et al. (2006)
Sa Spx	Negative	Upregulation of icaR	Pamp et al. (2006)
Se Spx	Negative	Unknown, but not through icaR	Wang et al. (2010)
Sa SrrAB	Positive	Direct binding to icaADBC promoter	Ulrich et al. (2007)
Se Ygs	Positive	Unknown	Wang et al. (2011)
Sa GdpS	Positive	Unknown	Holland et al. (2008)
Se Gdps			Tu Quoc et al. (2007)
Sa CcpA	Positive	Indirect, see text	Seidl et al. (2008)
Se CcpA			Sadykov et al. (2011)