Table 3.
GWAS association results for the most significant SNPs
| SNP | Chr | Minor/major allele | MAF | Location | Closest gene(s) | Cohort specific | Meta-analysis | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||||
| FHS OR (95% CI) | H2K OR (95% CI) | KORA F4 OR (95% CI) | OR | 95% CI | p-value | ||||||
| rs11653989 | 17 | A/T | 8.3% | Intergenic | MGAT5B, SEC14L | 0.43 (0.30–0.62) | 0.56 (0.29–1.07) | 0.49 (0.32–0.75) | 0.47 | 0.36–0.61 | 6.87×10−09 |
| rs6585436 | 10 | T/C | 1.7% | Intergenic | PDZD8, EMX2 | - | 0.43 (0.14–1.31) | 0.30 (0.19–0.49) | 0.32 | 0.21–0.50 | 4.88×10−07 |
| rs17029069 | 1 | T/C | 35.6% | Intronic | KCND3 | 1.58 (1.28–1.94) | 1.37 (0.94–2.02) | 1.32 (1.02–1.71) | 1.46 | 1.25–1.69 | 8.50×10−07 |
| rs17097328 | 14 | T/C | 19.0% | Intergenic | C14orf177 | 1.60 (1.27–2.02) | 1.44 (0.93–2.24) | 1.40 (1.04–1.86) | 1.51 | 1.27–1.78 | 1.71×10−06 |
| rs17012480 | 2 | A/G | 13.6% | Intronic | LTBP1 | 0.64 (0.51–0.80) | 0.88 (0.56–1.37) | 0.70 (0.54–0.93) | 0.69 | 0.58–0.81 | 6.97×10−06 |
| rs1541064 | 1 | A/G | 38.1% | Intronic | UBE2U | 1.70 (1.40–2.07) | 1.00 (0.66–1.51) | 1.11 (0.87–1.42) | 1.38 | 1.20–1.59 | 8.54×10−06 |
| rs6988260 | 8 | A/G | 21.0% | Intronic | FAM110B | 0.73 (0.59–0.91) | 0.51 (0.33–0.78) | 0.73 (0.54–0.98) | 0.69 | 0.59–0.81 | 8.92×10−06 |
| rs1382629 | 4 | A/G | 2.7% | Intronic | KIAA1211 | - | 1.66 (0.91–3.01) | 2.62 (1.69–4.09) | 2.23 | 1.56–3.18 | 9.82×10−06 |
Results sorted by ascending p-value. All results adjusted for age, sex, and RR-interval. Chr – chromosome; CI – confidence interval; GWAS – genome wide association study; ERP – early repolarization pattern; FHS – Framingham Heart Study; H2K – Health 2000 Study; MAF – minor allele frequency; OR – odds ratio per minor allele; SNP – single nucleotide polymorphism.