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Effect of NO-aspirin on β-catenin (A–C) and iNOS (D–F) in pancreatic tumors. Immunohistochemical analysis was performed with paraffin-embedded and microsectioned pancreatic tissues as described in Materials and Methods. (A–C) Immunohistochemical analysis of β-catenin, PCNA, and iNOS (D–F) expression in PanIN lesions and in ductal cells. A significantly decreased expression of β-catenin and iNOS expression was seen with low-dose NO-aspirin treatment.
