Table 2.

Relative Phosphorylation (Treatment/Control) of Proteins Regulated in Parallel in Response to Exposure of NCI-H526 Cells to Cisplatin and Titanocene Y.

Parallel Regulation	Cisplatin	SD	Titanocene Y	SD
Phosphorylated Protein	Mean		Mean
AMPKα1	2.64	0.44	2.61	0.23	NS
Fyn	1.32	0.31	2.29	0.17	NS
Hck	1.12	0.18	2.01	0.32	NS
Chk-2	1.42	0.41	1.71	0.49	NS
Lyn	1.01	0.03	1.27	0.03	*
TOR	0.66	0.11	0.94	0.16	NS
MEK1/2	0.63	0.03	0.87	0.15	NS
STAT5a-Tyr694	0.58	0.02	0.80	0.01	*
STAT2	0.47	0.08	0.74	0.11	NS
STAT5b-Tyr699	0.83	0.03	0.67	0.02	*
p70S6K-Thr389	0.22	0.16	0.67	0.45	NS
CREB	0.87	0.02	0.63	0.05	*
STAT4	0.28	0.01	0.58	0.04	*
Pyk2	0.36	0.04	0.55	0.06	NS
PLC-γ1	0.30	0.01	0.54	0.03	*
RSK1/2	0.21	0.02	0.52	0.03	*
MSK1/2	0.34	0.02	0.50	0.02	*
eNOS	0.24	0.00	0.47	0.02	*
p70S6K-Thr229	0.23	0.04	0.46	0.09	NS
p70S6K-Thr421/Ser424	0.26	0.03	0.45	0.13	NS
Src	0.28	0.02	0.40	0.03	*
Paxillin	0.20	0.02	0.39	0.01	*
Yes	0.22	0.02	0.38	0.02	*
p27-Thr198	0.11	0.04	0.35	0.12	NS
AMPKα2	0.35	0.03	0.33	0.05	NS
Akt-Thr308	0.23	0.07	0.32	0.13	NS
ERK1/2	0.11	0.01	0.21	0.01	*
β-Catenin	0.23	0.00	0.21	0.01	NS
c-Jun	0.25	0.01	0.19	0.00	NS
RSK1/2/3	0.08	0.00	0.17	0.01	NS
p53-Ser392	0.02	0.01	0.08	0.03	NS
p53-Ser46	0.01	0.07	0.07	0.14	NS
p53-Ser15	0.01	0.07	0.05	0.10	NS

Ratios are presented as mean ± SD; NS, difference not significant.

^*Difference significant, P < .05.