Table 1.
Activity of Taxanes on 1A9 Cells Overexpressing Wild-type or Control, Mutated SIRT2.
| Paclitaxel | IDN5390 | |||||
| Motility | Prol (72 hours) | Prol (4 hours) | Motility | Prol (72 hours) | Prol (4 hours) | |
| 1A9-S2 | 244.3 ± 141.1 | 4.6 ± 2.5 | 22.4 ± 14.5 | 143.5 ± 53.3 | 33.1 ± 15.3 | 241.9 ± 128.6 |
| 1A9-mutS2 | 24.5 ± 4.9 | 4.6 ± 2.1 | 34.4 ± 21.8 | 18.8 ± 5.9 | 41.9 ± 25.0 | 442.3 ± 49.1 |
Data are the IC50 values (in nM) and mean and SE of values from three experiments. Proliferation (prol) was assessed by exposing cells to the compounds for 4 hours (as in the motility assay) or 72 hours.