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. Author manuscript; available in PMC: 2013 Dec 11.
Published in final edited form as: Bioconjug Chem. 2012 Jun 11;23(6):1221–1229. doi: 10.1021/bc300039r

Figure 3.

Figure 3

ImmunoPET images of 89Zr-Df-rituximab on huCD20TM model. The representative images were scanned (5-20 minutes) at 4 - 120 h after tracer injection (7.4MBq/ 2-3μg of rituximab). Panels A-B, top (blocked = Pre-dose; control) and (non-blocked = no pre-dose; experiment) bottom rows are huCD20TM coronal images of pre-blocked and unblocked, respectively. Panel A are a mouse that received 4 mg/kg cold rituximab 2 h prior to tracer injection and panel B are mouse that received the PET tracer only. Panel C shows the CT and PET/CT images at 120 h after tracer injection for organ identification. Spleen is indicted by the yellow arrow. The other major organs are as marked (H= heart and L= liver). The color bar shows tracer %ID/g.