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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: J Appl Toxicol. 2012 Jul 4;32(11):913–919. doi: 10.1002/jat.2750

Table 2.

NCA parameters for IPPSF infusions of Ag-citrate and Ag-silicaa

Nanoparticle n t1/2λz (min) AUC0-∞ (μg*h/ml) Percentage AUC0-∞ Extrapolated (%) Mean Residence Time (min) Vz (ml) Cl (ml/min) Vdss (ml)
Ag-citrate 5 44 ± 13 185 ± 9.2 0.18 ± 0.067 11v± 4.7 73 ± 20 1.0 ± 0.05 12 ± 6
Ag-silica 4 59 ± 25 94 ± 28 1.8 ± 2.4 30 ± 34 135 ± 89 1.0 ± 0.4 50 ± 71
a

The NCA parameters included are t1/2λz=terminal phase half life, AUC0-∞=Area under concentration time curve from 0 to ∞, Vz=Volume of distribution during terminal phase, Cl=clearance, and Vdss=Volume of distribution at steady state.