. Author manuscript; available in PMC: 2013 Nov 1.

Published in final edited form as: J Appl Toxicol. 2012 Jul 4;32(11):913–919. doi: 10.1002/jat.2750

Table 3.

PK parameters for 2 compartmental model fit of Ag perfusion data^a

Nanoparticle	n	t_1/2_α (min)	t_1/2_β (min)	k₁₂ (h⁻¹)	k₂₁ (h⁻¹)	k₁₀ (h⁻¹)	t_1/2_elim (min)	V₁ (ml)	V₂ (ml)
Ag-citrate	5	2.4 ± 2.2	81 ± 38	0.26 ± 0.12	0.53 ± 0.25	17 ± 0.23	2.4 ±.2.2	6.1 ± 4.9	2.7 ± 0.67
Ag-silica	2	5.4	59	0.56	0.78	7.2	5.8	9.7	7.1
		1.5	377	0.46	0.11	28	1.5	2.2	9.2

Values for Ag-citrate are the X ± SDof the parameters estimated for the individual flaps, while the individual values for the 2 flaps are listed for Ag-silica. The parameters estimated include the half lives for the distribution and terminal phases, t_1/2_α and t_1/2_β, transfer rate constants between the central and peripheral compartments, k₁₂ and k₂₁, the elimination rate constant k₁₀, the half life of elimination, t_1/2elim, volume of the central compartment V₁, and volume of the peripheral compartment V₂.