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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Nat Genet. 2012 Sep 2;44(10):1126–1130. doi: 10.1038/ng.2387

Table 1.

Significantly associated genotyped SNPs at the HACE1 and LIN28B loci at 6q16

Discovery cohorta
European ancestry		 Italian replicationa
(TaqMan)		 CHOP replicationa
African American		 Combined
SNP A1/A2
(protective/
risk allele)		 Freq A1
cases
(n = 2,101 )		 Freq A1
controls
(n = 4,202)		 P b Freq A1
cases
(n = 351 )		 Freq A1
controls
(n = 780)		 P b Freq A1
cases
(n = 365)		 Freq A1
controls
(n = 2,491 )		 P c Meta
Pd 		ORe
(95% CIf)
HACE1
 rs4336470 T/C 0.30 0.35 1.8 × 10−8 0.30 0.34 0.060 0.62 0.70 1.4 × 10−3 2.7 × 10−11 1.26
(1.18–1.35)
 rs9404576 G/T 0.30 0.35 3.4 × 10−8 - - - 0.62 0.70 1.3 × 10−3 1.8 × 10−10 1.27
(1.18-1.36)
 rs4079063 G/A 0.43 0.47 4.0 × 10−5 - - - 0.70 0.78 1.3 × 10−4 1.3 × 10−7 1.20
(1.12-1.29)
 rs2499663 C/T 0.43 0.47 4.5 × 10−5 - - - 0.70 0.78 1.5 × 10−4 1.6 × 10−7 1.21
(1.13-1.29)
 rs2499667 G/A 0.43 0.47 2.6 × 10−5 - - - 0.71 0.78 2.6 × 10−4 1.2 × 10−7 1.21
(1.13-1.29)
LIN28B
 rs17065417 C/A 0.08 0.11 1.8 × 10−7 0.08 0.11 0.033 0.09 0.11 0.129 1.2 × 10−8 1.38
(1.23-1.54)
a

No deviations from Hardy-Weinberg equilibrium were observed (P > 0.001) in all cohorts.

b

P-values were calculated by allelic test.

c

P-values were calculated by logistic regression with percent African admixture as covariate12.

d

Meta-analysis P-value calculated using METAL14.

e

OR, odds ratio of risk allele based on meta-analysis.

f

CI, confidence interval.