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. Author manuscript; available in PMC: 2012 Sep 27.
Published in final edited form as: Cell Microbiol. 2007 Jun 24;9(11):2689–2699. doi: 10.1111/j.1462-5822.2007.00989.x

Fig. 4.

Fig. 4

Human CD11a specificity for Ltx resides in the N-terminal 128 amino acids. Human and mouse CD11a sequences were aligned and human domains were systematically replaced with their mouse counterparts. The resultant chimeric human/mouse CD11a molecules were transfected into the Ltx-resistant mutant J-β2.7 cell line, and tested for Ltx susceptibility demonstrating that only cells containing human CD11a residues 1–128 were Ltx sensitive. Cytotoxicity representative of at least four assays and shown as per cent wild-type (Jn.9) control. (*Significant; NS, not significant when compared with J-β2.7/hCD11a P < 0.001).