Table 2.
Comparison of hematological parameters (mean ± standard deviation) between individuals with normal genotype and those heterozygous for deletion -α3.7.
| Genotype | Gender | Hematological parameters | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||
| Hemoglobin (g/dL) | Erythrocytes (x1012/L) | MCV (fL) | MCH (pg) | Hb A2 (%) | Hb F (%) | |||||
|
|
|
|
||||||||
| M | F | M | F | M | F | |||||
| αα/αα (n = 623*) | 265 | 358 | 14.6 ± 1.1 | 12.8 ± 1.0 | 5.05 ± 0.41 | 4.46 ± 0.36 | 86.4 ± 4.8 | 28.8 ± 1.9 | 2.8 ± 0.5 | 0.4 ± 0.3 |
| -α3.7/αα (n = 77*) | 38 | 39 | 14.4 ± 1.0 | 12.3 ± 0.8 | 5.46 ± 0.50 | 4.79 ± 0.33 | 80.5 ± 4.5 | 26.18 ± 1.7 | 2.6 ± 0.6 | 0.5 ± 0.3 |
| p-value(**) | p = 0.211 | p = 0.003 | p < 0.001 | p < 0.001 | p < 0.001 | p < 0.001 | p = 0.020 | p = 0.750 | ||
| Reference values† | 15.0 ± 2.0 | 13.5 ± 1.5 | 5.00 ± 0.5 | 4.30 ± 0.5 | 92 ± 0.6 | 29.5 ± 2.5 | 2.4 ± 1.4 | < 1.0 | ||
M: male; F: female; MCV = mean corpuscular volume; MCH = mean corpuscular hemoglobin; Hb = hemoglobin.
*
10 samples with normal genotype and 2 with α+-thalassemia were excluded due to hemolysis and/or coagulation.
**
p-value of the Student’s t-test for independent samples.