Table 2.

Frequencies of micronucleated polychromatic erythrocytes (MNPCE) in bone marrow and peripheral blood of mice treated with different doses of oil-resin, and volatile and resinous fractions (500, 1,000 or 2,000 mg/kg b.w.) from commercial Copaiba oil-resin, and respective negative, positive (Doxorubicin, 16 mg/kg b.w., i.p.) and solvent (Tween 20) controls.

Treatments (mg/kg)	Bone marrow erythrocytes*		Peripheral blood erythrocytes**
	MNPCE Mean ± SD	PCE/NCE	MNPCE Mean ± SD
Negative control	3.83 ± 1.78	1.47 ± 0.44	1.50 ± 1.04
Solvent control	2.0 ± 1.41	1.42 ± 0.27	1.50 ± 1.22
Positive control	31.16 ± 7.90a, b	1.31 ± 0.14	14.16 ± 5.11a, b
Oil-resin
500	2.83 ± 1.72	1.26 ± 0.17	1.66 ± 1.50
1000	2.83 ± 0.75	1.74 ± 0.68	1.16 ± 0.75
2000	2.66 ± 0.81	1.48 ± 0.19	1.33 ± 1.03
Volatile fraction
500	2.16 ± 1.16	1.51 ± 0.21	1.33 ± 1.03
1000	2.66 ± 0.91	1.41 ± 0,21	0.83 ± 0.70
2000	4.16 ± 1.72	1.27 ± 0.33	1.33 ± 1.03
Resin fraction
500	4.66 ± 1.03	1.32 ± 0.27	2.16 ± 1.16
1000	2.50 ± 1.51	1.28 ± 0.12	1.83 ± 1.04

^*2,000 PCE were analyzed per animal, with six animals per group.

^**1,000 PCE were analyzed per animal.

^ap < 0.05 compared to negative control.

^bp < 0.05 compared to solvent control. One way-ANOVA and post-hoc Tukey test.