Table 1.

Top 30 Gene Ontology (GO) Terms Shared by the Known T1D Candidates

GO ID	GO name	No. of related genes	No. of all genes	p value
GO:0002376	Immune system process	119	419	8.96623E-57
GO:0006955	Immune response	107	324	1.11306E-56
GO:0006952	Defense response	66	262	1.16757E-29
GO:0048522	Positive regulation of cellular process	78	422	3.38945E-27
GO:0048518	Positive regulation of biological process	87	527	3.5746E-27
GO:0051707	Response to other organism	47	129	1.07228E-26
GO:0045321	Leukocyte activation	42	96	2.88314E-26
GO:0001775	Cell activation	43	107	1.01018E-25
GO:0009607	Response to biotic stimulus	47	163	4.75999E-23
GO:0046649	Lymphocyte activation	37	85	6.47356E-23
GO:0005102	Receptor binding	63	351	2.22003E-21
GO:0001816	Cytokine production	29	49	1.81449E-20
GO:0009891	Positive regulation of biosynthetic process	24	30	7.94301E-19
GO:0005126	Hematopoietin cytokine receptor binding	22	22	1.64226E-18
GO:0005125	Cytokine activity	36	114	1.98231E-18
GO:0051239	Regulation of multicellular organismal process	38	132	2.29147E-18
GO:0005615	Extracellular space	47	237	3.02711E-17
GO:0009893	Positive regulation of metabolic process	41	179	8.12675E-17
GO:0031325	Positive regulation of cellular metabolic process	40	171	1.19356E-16
GO:0042127	Regulation of cell proliferation	42	210	2.18148E-15
GO:0009611	Response to wounding	40	193	4.7197E-15
GO:0009605	Response to external stimulus	46	273	1.96122E-14
GO:0008283	Cell proliferation	51	349	7.50038E-14
GO:0044421	Extracellular region part	48	355	8.16255E-12
GO:0005886	Plasma membrane	84	939	1.40211E-11
GO:0044459	Plasma membrane part	73	778	6.85688E-11
GO:0008219	Cell death	45	365	9.93575E-10
GO:0016265	Death	45	365	9.93575E-10
GO:0006950	Response to stress	51	458	1.07864E-09
GO:0005515	Protein binding	163	2891	9.8504E-07

All human genes in the Human Protein Reference Database were used as reference.