Table 2.
Top 10 Protein Domains Over-Represented in Known T1D Candidates
| InterPro ID | InterPro short description | InterPro description | p value |
|---|---|---|---|
| IPR003597 | Ig_c1 | Immunoglobulin C1 type | 8.93E-34 |
| IPR007110 | Ig-like | Immunoglobulin-like | 2.64E-23 |
| IPR003006 | Ig_MHC | Immunoglobulin/major histocompatibility complex | 2.89E-22 |
| IPR013151 | Immunoglobulin | Immunoglobulin | 7.90E-21 |
| IPR013568 | SEFIR | SEFIR | 3.37E-19 |
| IPR004075 | IL1_rcpt_1 | Interleukin-1 receptor, type I/Toll precursor | 4.49E-16 |
| IPR000157 | TIR | Toll-interleukin receptor | 1.17E-15 |
| IPR001039 | MHC_I_alpha_A1A2 | MHC class I, alpha chain, alpha1 and alpha2 | 1.17E-15 |
| IPR007775 | LST1 | LST-1 | 3.04E-15 |
| IPR001003 | MHC_II_alpha_N | MHC class II, alpha chain, N-terminal | 1.93E-14 |