Table 5.

Gene Set Analysis of New and Known T1D Candidates

Comparison	RO versus HC	RO-HR versus HC-HR	RO-HR versus HRS	RO-LR versus HC-LR	RO-LR versus LRS
53 Novel candidates from the 6 T1D subnetworks	0.76	0.43	0.19	0.26	0.03
349 Candidates with PS>0.95	0.86	0.93	0.91	0.06	0.07
222 Known T1D candidates	0.23	0.20	0.12	0.52	0.85

The new candidates show signs of differential activity in cohorts with low-risk HLA genotypes.