Table 1.

Distribution of acute events according to children age and hemoglobin type

		0 to 3-year-old children	3 to 6-year-old children	Total	χ2#	p-value
		n (%)	n (%)	n (%)
Painful events		18/62 (29.0)	19/34 (55.9)	37/96 (38.5)
	Hb SS	16/49 (32.7)	17/30 (56.7)	33/79 (41.8)	4.412	0.03
	Hb SC	2/13 (15.4)	2/4 (50.0)	4/17 (23.5)
Splenic sequestration		36/62 (58.1)	10/34 (29.4)	46/96 (47.9)
	Hb SS	35/49 (71.4)	9/30 (30.0)	44/79 (55.7)	12.943	0.0001
	Hb SC	1/13 (7.7)	1/4 (25.0)	2/17 (11.8)
Hemolytic crisis		37/62 (59.8)	23/34 (67.6)	60/96 (62.5)
	Hb SS	35/49 (71.4)	22/30 (73.3)	57/79 (72.2)	0.034	0.85
	Hb SC	2/13 (15.4)	1/4 (25.0)	3/17 (17.6)
Foot-hand syndrome		21/62 (33.9)	14/34 (41.2)	35/96 (36.4)
	Hb SS	19/49 (38.8)	14/30 (46.7)	33/79 (41.8)	0.476	0.49
	Hb SC	2/13 (15.4)	0/4 (0)	2/17 (11.8)
	Infection	53/62 (85.5)	32/34 (94.1)	85/96 (88.5)
	Hb SS	42/49 (85.7)	28/30 (93.3)	70/79 (88.6)	1.070	0.47
	Hb SC	11/13 (84.6)	4/4 (100)	15/17 (88.2)
Acute chest syndrome		2/62 (3.2)	8/34 (23.5)	10/96 (10.4)
	Hb SS	2/49 (4.1)	8/30 (26.7)	10/79 (12.6)	8.585	0.005
	Hb SC	0/13 (0)	0/4 (0)	0/17 (0)

Hb SS = Hemoglobin SS (sickle cell anemia); Hb SC = hemoglobin SC;

# chi-square calculated only for events in children with Hb SS