Table 2.

A selection of online tools for predicting the functional effect of protein-coding variants

AlignGVGD	Conservation of physico-chemical properties	agvgd.iarc.fr
Condel	Prediction method based on combining other methods	bg.upf.edu/condel
MAPP	Conservation of physico-chemical properties	mendel.stanford.edu/sidowlab/downloads/MAPP
MutationTaster	Bayes classifier over multiple sequence features and conservation	mutationtaster.org
PMut	Evolutionary and structural features combined using a machine learning method	mmb2.pcb.ub.es:8080/PMut
PolyPhen-2	Evolutionary and structural features combined using naïve Bayes classifier	genetics.bwh.harvard.edu/pph2
SIFT	Evolutionary method based on position-specific scoring matrix	sift-dna.org
SNAP	Several evolutionary and structural features combined using a neural network	www.rostlab.org/services/snap
SNPs3D	Combination of a phylogenetic and a structural method. Uses support vector machine	www.snps3d.org