Table S1.
Genes tested but showing lack of association with chronic obstructive pulmonary disease
| Symbol | Name | Chromosome | References | |||
|---|---|---|---|---|---|---|
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| Single studies | Meta-analyses | |||||
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| Positive | Negative | Positive | Negative | |||
| AGER | Advanced glycosylation end product-specific receptor | 6 | 1,2 | |||
| CASP8 | Caspase 8, apoptosis-related cysteine peptidase | 2 | 3 | |||
| CCL17 (TARC) | Chemokine (C-C motif) ligand 17 | 16 | 4 | |||
| CCL2 | Chemokine (C-C motif) ligand 2 | 17 | 5 | |||
| CFLAR | CASP8 and FADD-like apoptosis regulator | 2 | 3 | |||
| COL6A5 | Collagen, type VI, alpha 5 | 3 | 6 | |||
| CXADR | Coxsackie virus and adenovirus receptor | 21 | 7 | |||
| CYP1B1 | Cytochrome P450, family 1, subfamily B, polypeptide 1 | 2 | 8,9 | |||
| CYP2D6 | Cytochrome P450, family 2, subfamily D, polypeptide 6 | 22 | 10 | |||
| DCN | Decorin | 12 | 11 | |||
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 19 | 12 | |||
| EDNRA | Endothelin receptor type A | 4 | 13 | |||
| FGA | Fibrinogen alpha chain | 4 | 14 | |||
| FGB | Fibrinogen beta chain | 4 | 14,15 | |||
| FGG | Fibrinogen gamma chain | 4 | 14 | |||
| FKBP4 | FK506 binding protein 4, 59 kDa | 12 | 12 | |||
| FKBP5 | FK506 binding protein 5 | 6 | 12 | |||
| FLCN | Folliculin | 17 | 16 | |||
| GABPA | GA binding protein transcription factor, alpha subunit 60 kDa | 21 | 17 | |||
| GPX1 | Glutathione peroxidase 1 | 3 | 18,19 | |||
| GSTM3 | Glutathione S-transferase mu 3 (brain) | 1 | 20 | |||
| HDAC2 | Histone deacetylase 2 | 6 | 1 | |||
| HDAC5 | Histone deacetylase 5 | 17 | 1 | |||
| HSP90AA1 (HSPCA) | Heat shock protein 90 kDa alpha (cytosolic), class A member 1 | 14 | 12 | |||
| HSP90AB1 (HSPCB) | Heat shock protein 90 kDa alpha (cytosolic), class B member 1 | 6 | 12 | |||
| HSPA1A | Heat shock 70 kDa protein 1A | 6 | 21 | |||
| HSPA1B | Heat shock 70 kDa protein 1B | 6 | 21 | |||
| HSPA1L | Heat shock 70 kDa protein 1-like | 6 | 21 | |||
| HSPA8 | Heat shock 70 kDa protein 8 | 11 | 12 | |||
| IL11 | Interleukin 11 | 19 | 1 | |||
| IL13RA2 | Interleukin 13 receptor, alpha 2 | X | 22 | |||
| ITGB5 | Integrin, beta 5 | 3 | 7 | |||
| JAK3 | Janus kinase 3 | 19 | 1 | |||
| KCND2 | Potassium voltage-gated channel, Shal-related subfamily, member 2 | 7 | 1 | |||
| MAP3K5 | Mitogen-activated protein kinase kinase kinase 5 | 6 | 1 | |||
| MIR146a | MicroRNA 146a | 5 | 23 | |||
| MRPL44 | Mitochondrial ribosomal protein L44 | 2 | 24 | |||
| ORMDL3 | ORM1-like 3 (S cerevisiae) | 17 | 25 | |||
| PTGES3 | Prostaglandin E synthase 3 (cytosolic) | 12 | 12 | |||
| RARRES2 | Retinoic acid receptor responder (tazarotene induced) 2 | 7 | 1 | |||
| SCGB1A1 (CC16) | Secretoglobin, family 1A, member 1 (uteroglobin) | 11 | 26 | |||
| SOD1 | Superoxide dismutase 1, soluble | 21 | 18,27 | |||
| TBX21 | T-box 21 | 17 | 28 | |||
| THSD4 | Thrombospondin, type I, domain containing 4 | 15 | 2 | |||
| TLR2 | Toll-like receptor 2 | 4 | 29,30 | |||
| TLR6 | Toll-like receptor 6 | 4 | 31 | |||
| TNFRSF1A | Tumor necrosis factor receptor superfamily, member 1A | 12 | 32 | |||
| TNFRSF1B | Tumor necrosis factor receptor superfamily, member 1B | 1 | 32 | |||