. Author manuscript; available in PMC: 2012 Sep 27.

Published in final edited form as: Am J Obstet Gynecol. 2009 Jun;200(6):595–609. doi: 10.1016/j.ajog.2009.04.005

TABLE 5.

Effect of magnesium sulfate on neonatal outcomes

Outcome	No of trials	Number of events/total number		Relative risk (95% Cl)	I² (%)
Outcome	No of trials	Magnesium	No magnesium	Relative risk (95% Cl)	I² (%)
Intraventricular hemorrhage (all grades)	5^30,31,33,35	467/2254	493/2298	0.96(0.86–1.08)	20.1
Grade III/IV intraventricular hemorrhage	4^30,31,35	74/1902	91/1962	0.83(0.61 1.11)	0.0
Periventricular leukomalacia	5^30,31,33,35	71/2254	76/2298	0.93(0.68–1.28)	0.0
Apgar score <7 at 5 minutes	3^31,33,35	351/2169	351/2218	1.03(0.90– 1.18)	7.3
Neonatal seizures	3^31,33,35	55/2169	70/2218	0.80(0.56–1.13)	0
Respiratory distress syndrome	2^33,35	730/1540	779/1592	1.01 (0.85–1.19)	65.8
Need for supplemental oxygen at 36 weeks	2^31,33	220/981	195/962	1.12(0.95–1.32)	23.1
Bronchopulmonary dysplasia	1³⁵	213/1188	218/1256	1.03(0.87–1.23)	NA
Mechanical ventilation	3^31,33,35	1381/2169	1446/2218	0.99(0.89–1.09)	82.1
Necrotizing enterocolitis	3^31,33,35	155/2169	131/2218	1.23(0.98–1.54)	0.0

Cl, confidence interval; NA, not applicable