Table 1.

Review of the literature

Reference	Extramedullary localization	Diagnostic test	Local therapy	Outcome portion	Cause of death
Goldberg and Mori [3]	Pericardial effusion and cardiac tamponade	Autopsy	NR	Death and postmortem diagnosis of pericardial involvement	Heart failure
Garrett et al. [4]	Pericardial and myocardial involvement and cardiac tamponade	Chest X-ray	Transthoracic pericardiocentesis	No medical therapy for heart involvement	Heart failure
Imamura et al. [5]	Pleural and pericardial effusion	NR	Pericardiocentesis, intrapericardial injection of OK-432, RT (1400rad), peplomycin, vincristine and prednisolone	CR	Death seven months after diagnosis for progression of systemic disease
Mitchell et al. [6]	Pericardial effusion and substantial hypertrophy of the right and left ventricular walls, infiltrative cardiomyopathy	Echocardiogram	Bleomycin 20mL in 30mL of normal saline solution introduced into the pericardial space	No recurrent pericardial effusion	36 hours after his last echocardiogram, the patient became acutely hypoxemic and died suddenly (massive pulmonary embolism) -no autopsy
Ueda et al. [8]	A-V sulcus between the left atrium and left ventricle (diameter 3cm) Cardiac tamponade	TEE	Cisplatin-betamethasone into the pericardial cavity	CR	Death from bacterial pneumonia 182 days after the first admission - no autopsy
Champeaux et al. [9]	Myocardium and coronary vessels	Autopsy	NR	NR	Respiratory failure
Owens et al. [10]	Pericardial effusion and large mass lesions in the left and right atria. Cardiac tamponade	Echocardiography, chest radiography and CT of the heart	Drainage of the effusion, RT to the heart (30Gy/10fr over two weeks with 6mV photons)	Almost complete tumor regression	Alive with disease
Zeiser et al. [11]	Pericardial and pleural effusion	Echocardiography, CT of the thorax	High-dose systemic dexamethasone	Stable disease for six weeks	Death from pneumonia
Songul et al. [12]	Left lobe and isthmus of thyroid, bilateral pleural effusion and a 1cm pericardial effusion around the left ventricle.	Chest radiography, CT	Chemotherapy, RT and supportive measures.	Death	Disease progression
Franzese et al. [13]	Pericardium infiltration	Chest radiography, CT and echocardiogram.	Surgical resection of the intrapericardial mass	NR	NR
Paulus et al. [14]	Large pericardial effusion, large right atrial mass encasing the interatrial septum extending into the left atrium, cardiac tamponade	Chest radiography, TEE, MRI of the chest, biopsy of the atrial mass	Pericardiocentesis, high-dose dexamethasone, bortezomib and lenalidomide RT to the cardiac mass (20Gy/10fr with 6mV photons using an Anterior-Posterior technique Consolidation unspecified chemotherapy (bortezomib, cyclophosphamide, dexamethasone)	Significant decrease in tumor size in the right atrium and the aortic root	NR

CT: computed tomography; MRI: magnetic resonance imaging; NR: not reported; RT: radiotherapy; TEE: transesophageal echocardiogram; OK-432 is an immunomodulator derived from Streptococcus; CR: complete remission.