Table 2.
Clinical manifestations, laboratory data, and outcome of 670 meningococcal disease patients with completed case records: serogroup CversusA
| Feature | Serogroup C (n = 493) | Serogroup A (n = 177) | P | |
|---|---|---|---|---|
| onset |
|
|
|
|
| Presentation days (mean ± SD) |
1.8 ± 2.5 |
1.9 ± 2.4 |
|
0.810 |
| Fever |
481(97.6) |
169(95.5) |
|
0.162 |
| Nausea and/or vomiting |
141(28.5) |
55(31.2) |
|
0.535 |
| Headache |
165(33.4) |
52(29.1) |
|
0.319 |
| Petechia and/or purpura |
396(80.3) |
126(73.4) |
|
0.063 |
| Altered mental status |
136(27.6) |
49(27.7) |
|
0.980 |
| Disease classification |
|
|
|
|
| Meningitis |
114(23.1) |
92(52.0) |
|
<0.001 |
| Meningococcemia |
379(76.9) |
85(48.0) |
|
|
| With Shock |
91(18.5) |
13(7.3) |
|
<0.001 |
| With pneumonia |
12(2.8) |
3(1.7) |
|
0.784 |
| With arthritis |
9 (1.8) |
4(2.3) |
|
0.967 |
| Complications |
161 |
23 |
|
<0.001 |
| Shock |
91(18.5) |
13(7.3) |
|
<0.001 |
| DIC |
60(12.2) |
7(4.0) |
|
0.002 |
| kidney failure |
10(2) |
3(1.7) |
|
0.783 |
| MOF |
4(0.8) |
1(0.6) |
|
1.0 |
| WBC count |
|
|
|
|
| >10 × 109/L |
302(61.3) |
99(56.1) |
|
0.019 |
| 10~4 × 109/L |
117(23.7) |
35(19.8) |
|
|
| <4 × 109/L |
74(15.0) |
43(24.3) |
|
|
| Platelet count |
|
|
|
|
| >100 × 109/L |
361(73.2) |
162(91.5) |
|
<0.001 |
| 100~50 × 109/L |
87(17.6) |
11(6.2) |
|
|
| 100~50 × 109/L |
87(17.6) |
11(6.2) |
|
|
| CSF data (mean ± SD) |
|
|
|
|
| Glucose level(mmol/L) |
2.07 ± 1.7 |
1.91 ± 1.8 |
|
0.717 |
| CSF glucose / blood glucose ratio |
0.24 ± 0.23 |
0.21 ± 0.29 |
|
0.438 |
| Total protein level(g/L) |
3.41 ± 2.9 |
3.17 ± 2.18 |
|
0.106 |
| Lactate level(mmol/L) |
10.4 ± 9.2 |
11.0 ± 8.9 |
|
0.113 |
| WBC count(109/L) |
5.3 ± 13.8 |
8.1 ± 13.6 |
|
0.895 |
| Sequelae |
46/484(9.5) |
6/171(3.5) |
|
0.013 |
| Scars |
19/484(3.9) |
2/171(1.2) |
|
0.132 |
| Amputations |
14/484(2.9) |
0 |
|
0.026 |
| sensorineural hearing loss |
5/484(1.0) |
3/171(1.8) |
|
0.739 |
| Others |
8/484(17) |
1/171(0.6) |
|
0.516 |
| Death | 55/484(11.4) | 9/171(5.3) | 0.021 |
NOTE. Data are no. (%) of patients, unless otherwise indicated.
WBC: white blood cells. DIC: disseminated intravascular coagulation.
MOF: multiple organ failure.