Table 1.
ORs and heterogeneity results for the genetic contrasts of MTHFR C677T polymorphism for ALL risk
| Genetic Model | Studies | I2, (%) | P, Q Testa |
Fixed-effect |
Random-effect |
|
|---|---|---|---|---|---|---|
| OR | OR | |||||
| All |
Allele contrast |
34 |
58 |
0.000 |
0.92(0.88-0.97) |
0.91(0.83-0.99) |
| |
Dominant model |
34 |
58 |
0.000 |
0.92(0.86-0.98) |
0.90(0.80-1.02) |
| |
Recessive model |
33 |
22 |
0.129 |
0.86(0.77-0.96) |
0.85(0.74-0.98) |
| |
Additive mode |
33 |
39 |
0.013 |
0.82(0.73-0.93) |
0.80(0.68-0.95) |
| All in HWE |
Allele contrast |
31 |
61 |
0.000 |
0.92(0.87-0.97) |
0.90(0.82-0.99) |
| |
Dominant model |
31 |
60 |
0.000 |
0.92(0.86-0.99) |
0.90(0.80-1.02) |
| |
Recessive model |
30 |
25 |
0.109 |
0.85(0.76-0.96) |
0.84(0.72-0.97) |
| |
Additive model |
30 |
41 |
0.011 |
0.82(0.72-0.92) |
0.78(0.65-0.94) |
| Children |
Allele contrast |
25 |
56 |
0.000 |
0.92(0.87-0.98) |
0.90(0.82-0.997) |
| |
Dominant model |
25 |
60 |
0.000 |
0.92(0.85-0.99) |
0.90(0.79-1.03) |
| |
Recessive model |
24 |
0 |
0.479 |
0.85(0.74-0.96) |
0.86(0.75-0.98) |
| |
Additive model |
24 |
23 |
0.158 |
0.82(0.71-0.94) |
0.80(0.67-0.95) |
| Adults |
Allele contrast |
6 |
75 |
0.001 |
0.95(0.83-1.09) |
0.95(0.71-1.26) |
| |
Dominant model |
6 |
67 |
0.010 |
0.94(0.77-1.14) |
0.96(0.68-1.35) |
| |
Recessive model |
6 |
66 |
0.012 |
0.93(0.72-1.22) |
0.85(0.52-1.40) |
| |
Additive model |
6 |
74 |
0.002 |
0.89(0.67-1.19) |
0.82(0.44-1.52) |
| Adults+children |
Allele contrast |
3 |
40 |
0.187 |
0.88(0.72-1.06) |
0.89(0.69-1.14) |
| |
Dominant model |
3 |
52 |
0.126 |
0.85(0.64-1.12) |
0.86(0.57-1.29) |
| |
Recessive model |
3 |
31 |
0.236 |
0.85(0.60-1.20) |
0.85(0.55-1.39) |
| |
Additive model |
3 |
30 |
0.241 |
0.77(0.52-1.14) |
0.79(0.49-1.26) |
| East Asians |
Allele contrast |
7 |
65 |
0.009 |
0.92(0.83-1.02) |
0.95(0.79-1.15) |
| |
Dominant model |
7 |
60 |
0.020 |
0.90(0.78-1.04) |
0.95(0.74-1.22) |
| |
Recessive model |
7 |
53 |
0.047 |
0.89(0.72-1.09) |
0.91(0.66-1.24) |
| |
Additive model |
7 |
60 |
0.020 |
0.87(0.69-1.09) |
0.90(0.62-1.32) |
| Caucasians |
Allele contrast |
15 |
54 |
0.006 |
0.89(0.83-0.96) |
0.85(0.76-0.95) |
| |
Dominant model |
15 |
54 |
0.007 |
0.88(0.80-0.96) |
0.82(0.70-0.95) |
| |
Recessive model |
15 |
27 |
0.155 |
0.85(0.73-0.98) |
0.82(0.68-0.99) |
| Additive model | 15 | 40 | 0.053 | 0.80(0.69-0.93) | 0.74(0.59-0.92) |
All = all of the studies meet the inclusion criteria; All in HWE = all of the studies meet the inclusion criteria except ones with genotype distribution of the controls deviating from HWE; HWE = Hardy-Weinberg Equilibrium.
a Q test is to estimate heterogeneity between studies. P < 0.10 indicates significant heterogeneity.