Table 3. Association analysis of SNPs in TNF, LTA, TNFRSF1A and TNFRSF1B between case and control groups.
| Gene | Healthy | Sepsis | Severe sepsis | Allelic Comparison | Genotypic Comparison | ||||
| SNP | controls | patients | patients | P1 adj | OR1 adj 95% CI | P2 adj | OR2 adj 95% CI | P1 adj | P2 adj |
| TNF | |||||||||
| rs1800629 | 0.00046 | 1.92 (1.26–2.92) | 0.002 | 1.56 (1.23–2.76) | 0.003 | 0.004 | |||
| GG | 560 (93.3%) | 352 (93.9%) | 369 (86.4%) | ||||||
| GA | 38 (6.3%) | 23 (6.1%) | 56 (13.1%) | ||||||
| AA | 2 (0.3%) | 0 (0%) | 2 (0.47%) | ||||||
| G | 1158 (96.5%) | 727 (96.9%) | 794 (93%) | ||||||
| A | 42 (3.5%) | 23 (3.1%) | 60 (7%) | ||||||
| rs361525 | 0.22 | 1.09 (0.98–1.87) | 0.88 | 1.02 (0.84–1.42) | 0.21 | 0.89 | |||
| CC | 550 (92%) | 333 (88.8%) | 382 (89.3%) | ||||||
| CT | 48 (8%) | 42 (11.2%) | 46 (10.7%) | ||||||
| C | 1148 (96%) | 708 (94.4%) | 810 (94.6%) | ||||||
| T | 48 (4%) | 42 (5.6%) | 46 (5.4%) | ||||||
| rs1799724 | 0.21 | 1.18 (0.98–2.01) | 0.52 | 1.06 (0.86–1.46) | 0.12 | 0.85 | |||
| GG | 444 (73.6%) | 263 (70.3%) | 285 (67.9%) | ||||||
| GA | 149 (24.7%) | 107 (28.6%) | 130 (31%) | ||||||
| AA | 10 (1.7%) | 4 (1.1%) | 5 (1.2%) | ||||||
| G | 1037 (86%) | 633 (84.6%) | 700 (83.3%) | ||||||
| A | 169 (14%) | 115 (15.4%) | 140 (16.7%) | ||||||
| rs1799964 | 0.62 | 1.02 (0.92–1.42) | 0.56 | 1.12 (0.84–1.46) | 0.87 | 0.52 | |||
| TT | 384 (64.4%) | 234 (62.2%) | 265 (62.6%) | ||||||
| TC | 188 (31.5%) | 130 (34.6%) | 140 (33.1%) | ||||||
| CC | 24 (4%) | 12 (3.2%) | 18 (4.3%) | ||||||
| T | 956 (80.2%) | 598 (79.5%) | 670 (79.2%) | ||||||
| C | 236 (19.8%) | 154 (20.5%) | 176 (20.8%) | ||||||
| rs1800630 | 0.32 | 1.09 (0.81–1.40) | 0.38 | 1.18 (0.72–1.43) | 0.12 | 0.42 | |||
| CC | 412 (69%) | 262 (70.6%) | 275 (66.3%) | ||||||
| AC | 179 (30%) | 102 (27.5%) | 128 (30.8%) | ||||||
| AA | 6 (1%) | 7 (1.9%) | 12 (2.9%) | ||||||
| C | 1003 (84%) | 626 (84.4%) | 678 (81.7%) | ||||||
| A | 191 (16%) | 116 (15.6%) | 152 (18.3%) | ||||||
| LTA | |||||||||
| rs909253 | 0.18 | 0.89 (0.79–1.21) | 0.36 | 0.82 (0.58–1.26) | 0.29 | 0.14 | |||
| AA | 178 (29.7%) | 103 (27.8%) | 140 (33.6%) | ||||||
| AG | 266 (44.4%) | 181 (48.9%) | 181 (43.5%) | ||||||
| GG | 155 (25.9%) | 86 (23.2%) | 95 (22.8%) | ||||||
| A | 622 (51.9%) | 387 (52.3%) | 461 (55.4%) | ||||||
| G | 576 (48.1%) | 353 (47.7%) | 371 (44.6%) | ||||||
| TNFRSF1A | |||||||||
| rs767455 | 0.16 | 1.20 (0.82–1.68) | 0.72 | 1.04 (0.76–1.23) | 0.27 | 0.76 | |||
| AA | 462 (76.4%) | 276 (73.4%) | 302 (71.4%) | ||||||
| GA | 131 (21.7%) | 90 (23.9%) | 112 (26.5%) | ||||||
| GG | 12 (2.0%) | 10 (2.7%) | 9 (2.1%) | ||||||
| A | 1055 (87.2%) | 642 (85.4%) | 716 (84.6%) | ||||||
| G | 155 (12.8%) | 110 (14.6%) | 130 (15.4%) | ||||||
| rs4149570 | 0.78 | 0.96 (0.67–1.09) | 0.41 | 1.09 (0.82–1.34) | 0.86 | 0.62 | |||
| GG | 178 (29.3%) | 118 (31.6%) | 123 (29.2%) | ||||||
| GT | 303 (49.9%) | 192 (51.3%) | 212 (50.4%) | ||||||
| TT | 126 (20.8%) | 64 (17.1%) | 86 (20.4%) | ||||||
| G | 659 (54.3%) | 428 (57.2%) | 458 (54.4%) | ||||||
| T | 555 (45.7%) | 320 (42.8%) | 384 (45.6%) | ||||||
| TNFRSF1B | |||||||||
| rs1061622 | 0.32 | 0.92 (0.87–1.28) | 0.32 | 1.02 (0.91–1.46) | 0.35 | 0.38 | |||
| TT | 398 (65.9%) | 262 (69.7%) | 297 (70.5%) | ||||||
| TG | 190 (31.5%) | 102 (27.1%) | 116 (27.6%) | ||||||
| GG | 16 (2.6%) | 12 (3.2%) | 8 (1.9%) | ||||||
| T | 986 (81.6%) | 626 (83.2%) | 710 (84.3%) | ||||||
| G | 222 (18.4%) | 126 (16.8%) | 132 (15.7%) | ||||||
| rs3397 | 0.48 | 1.04 (0.92–1.41) | 0.17 | 1.28 (0.94–1.68) | 0.30 | 0.32 | |||
| GG | 255 (41.9%) | 156 (41.8%) | 158 (37.6%) | ||||||
| AG | 304 (49.9%) | 194 (52%) | 232 (55.2%) | ||||||
| AA | 50 (8.2%) | 23 (6.2%) | 30 (7.2%) | ||||||
| G | 814 (66.8%) | 506 (67.8%) | 548 (65.2%) | ||||||
| A | 404 (33.2%) | 240 (32.2%) | 292 (34.8%) | ||||||
SNP, single nucleotide polymorphism; OR, odds ratio; CI, confidence interval. Padj and ORadj came from multivariate logistic regression. P1 adj and OR1 adj, healthy control group vs severe sepsis group. P2 adj and OR2 adj, sepsis group vs severe sepsis group. A P-value of <0.005 (0.05/10) was considered statistically significant after Bonferroni correction.