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. 2012 Sep 27;7(9):e45963. doi: 10.1371/journal.pone.0045963

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© 2012 Sheng et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Application of the calcium channel blocker nifedipin completely stopped action potential generation in day 60 hiPSC-CMs (A) and day 60 hESC-CMs (B) at a concentration of 10 µM. Application of 1 µM nifedipin resulted in a strong shortening of the action potential. Application of lidocain could completely prevent action potentials in hiPSC-CMs at a concentration of 50 µM (C), in hESC-CMs 1000 µM abrogated action potential generation.