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. 2012 Sep 27;7(9):e44951. doi: 10.1371/journal.pone.0044951

Figure 2. Methylation of the CDO1 promoter in multiple types of human cancer. A.

Figure 2

, Quantitative methylation levels of CDO1 were determined in primary tissues derived from breast, esophagus, lung, bladder, and stomach. TaqMan methylation values (TaqMeth V) is described in Materials and Method. PT, primary tumor; PN, matched normal tissues; NN, normal tissues from non-cancer patients; CL, cell lines. Lines indicate the optimal cut-off value for each tissue. Arrow, MCF-12A, a non-tumorigenic cell line, harbored a low level of CDO1 methylation (TaqMeth V, 6.2). All assays were performed in duplicate format, and experiments were repeated twice. Data showed reproducible and concordant results. B, ROC analysis (PT vs. PN) of CDO1 in multiple human cancers. Solid line, CDO1; dashed line, no discrimination.