Table 4. Immunohistochemical analysis of CDO1 in esophageal cancer tissue microarray with normal tissue controls (ES804).

		Grade	CDO1 (+)	%	P value
a Normal	Total		30/30	100
	Normal		10/10	100
	Chronic esophagitis		10/10	100
	Hyperplasia		10/10	100
Malignant	Total		14/49	28.6
	Adenocarcinoma	Subtotal	4/20	20.0	<0.001 *
		II	2/10	20.0
		II–III, III	2/8	25.0
		Adenosquamous carcinoma	0/1	0
		Basaloid squamous cell carcinoma	0/1	0
	Squamous cell carcinoma	Subtotal	9/20	45.0	<0.001 *
		I	7/11	63.6
		I–II, II	1/5	20.0
		III	1/4	25.0
	Metastatic cancer	Subtotal	1/9	11.1	<0.001 *
		Metastatic adenocarcinoma	0/3	0
		Metastatic squamous cell carcinoma	1/6	16.7

Expression level was indicated as −, absent or faint expression; +, moderate expression; ++, expression; +++, strong expression.

CDO1 positivity (+) was counted in samples with over moderate expression.

P values from Fisher’s exact test performed in normal vs. adenocarcinoma, squamous cell carcinoma, or metastatic cancer.

^*P<0.05 considered significant.

^aNon-malignant normal esophagus tissue and cancer adjacent normal esophagus tissue.