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. 2012 Sep 27;8(9):e1002986. doi: 10.1371/journal.pgen.1002986

Figure 4. TCF7L2 does not require β-catenin for the regulation of hepatic glucose metabolism.

Figure 4

(A–C) Q-PCR analysis showing effects of β-catenin expression on TCF7L2-dependent regulation of gluconeogenic genes in primary hepatocytes (n = 3 for each group). Representative data from at least three independent experiments are shown. D–F) Q-PCR analysis showing effects of β-catenin knockdown on TCF7L2-dependent regulation of gluconeogenic gene expression in primary hepatocytes from either TCF7L2 +/+ (+/+) or TCF7L2 +/− mice (+/−) (n = 3 for each group). Representative data from at least three independent experiments are shown. Data in A–F) represent mean ± SD (*;P<0.05, **;P<0.005, ***;P<0.0005, t-test).