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. 2012 Sep 27;8(9):e1002986. doi: 10.1371/journal.pgen.1002986

Figure 5. Chronic depletion of TCF7L2 promotes increased glucose production from the liver.

Figure 5

A) Effects of haploinsufficiency of TCF7L2 on glucose metabolism. 16 h fasting glucose levels (left) or 6 h fasting glucose levels (right) from 8-week-old TCF7L2 +/+ (n = 10) and TCF7L2 +/− (n = 10) male mice under the normal chow diet were shown. B) Pyruvate tolerance test showing effects of chronic depletion of TCF7L2 on glucose homeostasis under 16 h fasting conditions (n = 10 for TCF7L2 +/+ mice, and n = 10 for TCF7L2 +/− mice). C) Q-PCR analysis showing expression levels of gluconeogenic genes in livers of TCF7L2 +/+ and TCF7L2 +/− mice fasted for 6 h (n = 5 for TCF7L2 +/+ mice, and n = 5 for TCF7L2 +/− mice). D) Effects of haploinsufficiency of TCF7L2 on body weight, blood glucose, serum insulin, and serum IGFBP1 levels under feeding conditions (n = 8 for TCF7L2 +/+ mice, and n = 8 for TCF7L2 +/− mice). E) Pyruvate tolerance test showing effects of chronic depletion of TCF7L2 on glucose homeostasis under feeding conditions (n = 8 for TCF7L2 +/+ mice, and n = 8 for TCF7L2 +/− mice). F) Q-PCR analysis showing expression levels of gluconeogenic genes in livers of TCF7L2 +/+ and TCF7L2 +/− mice under feeding conditions (n = 7 for TCF7L2 +/+ mice, and n = 7 for TCF7L2 +/− mice). Data in A), B), D), and E) represent mean ± SEM, and data in C) and F) represent mean ± SD (*;P<0.05, **;P<0.005, ***;P<0.0005, t-test).