Fig. 1.

Schematics of LOX family oxidases. LOX and LOX-like proteins (LOXL) 1–4 are synthesized as proenzymes. LOX family oxidases are highly conserved at their C- terminal mature domains, including the copper binding site, the lysyl tyrosyl quinine (LTQ) cofactor residues, and the cytokine receptor like (CRL) domain, but differ significantly at their N- terminal pro-peptides. The pro-peptides, especially the proline-rich domain in LOXL1 and the scavenger-receptor cysteine-rich (SRCR) domains in LOXL2-4, are possibly involved in protein-protein interactions. Si: Signal peptide