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Effects of 2-aminoethoxydiphenylborate (2-APB, A) and gadolinium chloride hexahydrate (Gd3+, B) on dexmedetomidine-induced concentration-response curves in endothelium-denuded aorta. Data are shown as the mean ± SD and expressed as the percentage of the maximum contraction induced by isotonic 30 mM KCl. ED50: *P < 0.05 and †P < 0.001 versus no drug; ‡P < 0.05 versus 5 × 10-6 M 2-APB. Maximal contraction: §P < 0.05 and ∥P < 0.001 versus no drug; ¶P < 0.001 versus 10-5 M 2-APB.
