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. 2012 Sep 28;3:192. doi: 10.3389/fgene.2012.00192

Table 2.

Top KEGG pathways in the brains of MAM-treated mice and associated miRNAs in human cancers.

Top MAM-associated KEGG pathways in mouse brain Genes Phenotype miR-1/miR- 133A-regulated in human cancers*
Pathways in cancer 13 CC Yes
Wnt signaling 10 AD, CC Yes
Insulin signaling 9 AD, ALS
Purine metabolism 9
Prostate cancer 8 CC
MAPK signaling 7 AD, CC Yes
Melanogenesis 6 PD? CC
Neurotrophin signaling 6 AD
Focal adhesion 6 AD, CC Yes
Chemokine signaling 5 AD Yes
Neuroactive ligand-receptor interaction 5 AD
Calcium-signaling pathway 4 AD, CC Yes

Top brain KEGG pathways (derived from 443 MAM-modulated genes) and the number of MAM-modulated genes and human diseases associated with each pathway. AD, Alzheimer disease; ALS, amyotrophic lateral sclerosis; CC, colon cancer; PD, idiopathic Parkinson’s disease (modified from Kisby et al., 2011a). The right-hand column shows the biological processes or signaling pathways potentially regulated by the miR-1/miR-133a cluster in human cancers examined by *Nohata et al. (2012). Additional signaling pathways in Nohata and colleagues’ top 20 included those related to the glutamatergic synapse and axon guidance, both of which are perturbed by MAM.