Table 2.
Top KEGG pathways in the brains of MAM-treated mice and associated miRNAs in human cancers.
| Top MAM-associated KEGG pathways in mouse brain | Genes | Phenotype | miR-1/miR- 133A-regulated in human cancers* |
|---|---|---|---|
| Pathways in cancer | 13 | CC | Yes |
| Wnt signaling | 10 | AD, CC | Yes |
| Insulin signaling | 9 | AD, ALS | |
| Purine metabolism | 9 | ||
| Prostate cancer | 8 | CC | |
| MAPK signaling | 7 | AD, CC | Yes |
| Melanogenesis | 6 | PD? CC | |
| Neurotrophin signaling | 6 | AD | |
| Focal adhesion | 6 | AD, CC | Yes |
| Chemokine signaling | 5 | AD | Yes |
| Neuroactive ligand-receptor interaction | 5 | AD | |
| Calcium-signaling pathway | 4 | AD, CC | Yes |
Top brain KEGG pathways (derived from 443 MAM-modulated genes) and the number of MAM-modulated genes and human diseases associated with each pathway. AD, Alzheimer disease; ALS, amyotrophic lateral sclerosis; CC, colon cancer; PD, idiopathic Parkinson’s disease (modified from Kisby et al., 2011a). The right-hand column shows the biological processes or signaling pathways potentially regulated by the miR-1/miR-133a cluster in human cancers examined by *Nohata et al. (2012). Additional signaling pathways in Nohata and colleagues’ top 20 included those related to the glutamatergic synapse and axon guidance, both of which are perturbed by MAM.