Table 1.

Expression patterns of select TNFSF/TNFRSF members in neuronal tissue in healthy mammals.

TNFRSF/TNFSF member	Species	Period of developmenta	Cell type	Region	Reference
Fas and Fas L	Mouse	ED15-18	Non-endothelial	Hippocampus, cortex, ventricular zone	French et al. (1996); Zuliani et al. (2006)
					Choi et al. (1999)
Fas and Fas L	Human	Fts 20-25 weeks	Astrocytes		Zuliani et al. (2006)
Fas and Fas L	Mouse	PD1	Neurons, oligodendrocytes	Hippocampus, cortical layers II, III and V	Knight et al. (2010)
Fas and Fas L	Mouse	PD4	Neural progenitors		Zuliani et al. (2006)
Fas and Fas L	Mouse	PD5 (peak)	Neurons	Hippocampus, CA2 and CA3	Zuliani et al. (2006)
Fas	Mouse	PD14	Endothelial	dentate gyrus, CA1	Park et al. (1998)
	Mouse		Neurons		Harry et al. (2008)
FasL	Mouse	PD21 (low)	Neurons	Scattered throughout	French et al. (1996)
Fas and Fas L	Mouse				Matsuyama et al. (1994)
Fas and Fas L	Mouse				Corsini et al. (2009)
Fas	Mouse	Ad (low)	Neural progenitors	Dentate gyrus, SVZ	Knight et al. (2010)
Fas and Fas L	Mouse	Ad (high)	Neural progenitors	Scattered throughout	Choi et al. (1999)
FasL	Human	Ad (high)	Astrocytes		Bechmann et al. (1999)
FasL	Rat	Ad (high)	Astrocytes		Bechmann et al. (1999)
FasL	Human	Ad	Neurons	Associated with blood vasculature	Bechmann et al. (1999)
FasL	Human	Ad	Astrocytes	Associated with blood vasculature
TNF	Mouse	ED10-19			Yamasu et al. (1989)
TNF	Human	Fts 18 weeks	Astrocytes		Lee et al. (1993)
TNF	Sheep	ED30-lst trimester		Ventricular & Marginal zone, white matter	Dziegielewska et al. (1994)
TNF	Human	Fts	Astrocytes		Lee et al. (1993)
TNF	Human	Fts	Microglia		Williams et al. (1995)
	Rat	Fts	Glia		Schwartz et al. (1998)
TNF	Mouse	PD7 (Peak)			Yamasu et al. (1989)
TNF	Human	Ad	Microglia		Becher et al. (1996)
TNF	Rat	Ad		Throughout including cortex, hippocampus	Cearly et al. (2003)
TNFR1/TNFR2	Mouse	ED10-19		throughout including hippocampus and cerebellum	Neumann et al. (2002); Yang et al. (2002); Oldrieve et al. (2010)
					Keohane et al. (2010)
TNFR1/TNFR2	Rat	Fts	Neural progenitor cells	(reported to be TNF sensitive)	Hurwitz et al. (1992)
TNFR?	Human	Fts	Astrocytes	(reported to be TNF sensitive)	Moretto et al. (1993)
TNFR?	Human	Fts	Astrocytes		Sheng et al. (2005)
TNFR1/TNFR2	Human	Fts 8-10 weeks	Neural progenitor cells	Hippocampus	Kajiwara et al. (2005)
TNFR1	Rat	Fts ED16	Neurons	Hippocampus	Harry et al. (2008)
TNFR1/TNFR2	Mouse	PD21	Neurons primarily	Cerebellum	Oldrieve et al. (2010)
TNFR1/TNFR2	Mouse	Ad (high)	Neurons	Hippocampus	Iosif et al. (2006)
TNFR1/TNFR2	Mouse	Ad	Neurons	Hippocampus	Dopp et al. (1997), Iosif et al. (2006)
TNFR1/TNFR2	Mouse	Ad (low)	Neural progenitor cells	Throughout, especially hippocampus	Balosso et al. (2005)
TNFR2	Mouse	Ad	Neurons	Cortex	Patel et al. (2008)
TNFR1/TNFR2	Rat	Ad (10 months - high)	Neurons	Cortex	Patel et al. (2008)
TNFR1/TNFR2	Rat	Ad (24 months - high)	Neurons		Dopp et al. (1997)
TNFR1	Rat	PD6-15	Glia		Dopp et al. (1997)
TNFR2	Rat		Astrocytes		Dopp et al. (1997)
TNFR2	Rat		Oligodendrocytes
DR3	Mouse	ED12-13 then downregulated before birth		Mesencephalic ventricle, midbrain, roof of neopallial cortex	Harrison et al. (2000)
		PD6-7 into
		Ad
		Ad		Throughout
DR3	Mouse	Ad		Throughout including hippocampus, cortex	Wang et al. (2001)
DR3	Mouse	Ad	Neurons	Throughout including cortex, striatum, hip- pocampus and cerebellum	Twohig et al. (2010)
DR3	Human	Ad		Throughout including hippocampus, cortex	Newman et al. (2000)
DR3	Rat				Harrison et al. (2000)
TL1A	Mouse		Astrocytes		Twohig et al. (2010)
p75NTR	Mouse	ED	Radial glial cells		Mathius et al. (2010)
p75NTR	Human	Fts 14-20 weeks (high)	Neurons	Throughout including cerebellum, neocor- tex and hippocampus. Positional changes with development
		Fts 22 weeks - birth (low)
p75NTR	Human	Ad (high)	Neurons	Primarily forebrain but in other places	Kordower et al. (2002)
		Ad (high)		Primarily forebrain and cerebellum
p75NTR	Mouse		Neurons		Salama-Cohen et al. (2005)
p75NTR	Rat	Ad (high)	Neurons	Forebrain	Pioro et al. (1990); Hartig et al. (1998)
		Ad (high)		Primarily forebrain and cerebellum but in other places	Hefti et al. (1986)
p75NTR	Human		Neurons	Primarily forebrain but in other places	Kordower et al. (1988); Kordower et al. (1994)
p75NTR	Monkey	Ad (low)	Neurons		Mufsan et al. (1989, 1992)
p75NTR	Human		Neurons
TROY	Mouse	ED11.5-13.5	Radial glial cells, Neuroepithelial cells	Forebrain, mid brain- ventricular/subven- tricular zone, olfactory bulb, telencephalic neuroepithelium, dorsal neural tube Forebrain, hippocampus-dentate SVZ dentate gyrus	Kojima et al. (2000); Hisaoka et al. (2003, 2006a,b);Morikawa et al. (2008)
TROY	Mouse				Hisaoka et al. (2006a)
			Radial glial cells	Molecular Layer	Hisaoka et al. (2006a)
TROY	Mouse	ED15.5-17.5		Hippocampal hilus, DG subgranular zone
			Radial Glial/astrocyte	Cerebral cortex-microvascular associated
			progenitors
TROY	Mouse	Post-natal	Radial glial cells	Throughout including forebrain, hippocam- pus, striatum and cortex	Park et al. (2005)
			Neurons	Cortex and hippocamus
TROY	Mouse	PD7-14		Forebrain, hippocampus, striatum, cortex, amygdale, thalamus, midbrain, cerebellum, olfactory bulb particularly rostral migratory	Trifunofski et al. (1996)
				stream and SVZ
TROY	Mouse	PD28		Scattered throughout	Hisaoka et al. (2006a,b)
			Neuronal progenitor cells
TROY	Rat	Ad		Scattered throughout cortex, hippocampus and striatum
TROY	Mouse	Ad			Sotah et al. (2007)
TROY	Human	Aged Ad (high)	Neurons and astrocytes, most microglia
TROY	Mouse	Ad	Astrocytes and glia		Hisaoka et al. (2006a,b)
CD40L	Mouse	Newborn/Ad	Microglia, Astrocytes	Scattered throughout whole brain	Tan et al. (2002)
					Calingasan et al. (2002)
	Mouse	Very Aged Ad	Smooth muscle, Endothelial cells, Microvasculature	Hippocampus, cortex	Calingasan et al. (2002)
			Neurons		Calingasan et al. (2002)
CD40	Mouse	Ad		Hippocampus, DG and pyramidal cell layer	Tan et al. (2002)
					Hou et al. (2008)
GITRL/GITR	Mouse	ED15-18	Sympathetic Neurons	No expression in the brain,	O’Keeffe et al. (2008)
GITRL/GITR	Mouse	PD1-P5		Strong expression in the peripheral neurotissues
	Mouse	Ad
GITRL/GITR	Human	? (very low)			Gurney et al. (1999)
EDAR	Mouse	ED10-12		Thalamus, mid-brain, lateral ventricles	Pispa et al. (2003)
EDA	Mouse	ED10-12		Diencephalon, lateral ventricles, hindbrain	Pispa et al. (2003)

^aED, embryonic day; PD, post-natal day; Fts, fetus; Ad, adult.