Figure 3.

Regulation of T-cell responses by DR3 following viral infection. A) Time courses showing numbers of NK (i), CD4⁺ T (ii), and CD8⁺ T (iii) cells in the spleens from DR3^WT and DR3^KO mice following MCMV challenge. DR3^WT receiving PBS (●) or MCMV (▲); DR3^KO receiving PBS (○) or MCMV (). Each data point represents mean ± se from n ≥ 5 mice and is representative of 4 separate experiments. *P < 0.05 at indicated time points; Student’s t test. B) Relative expansion of CD4⁺ and CD8⁺ T cells compared to unchallenged controls following MCMV challenge at peak (d 6 for CD4⁺, d 7 for CD8⁺). Bars show means ± se from n ≥ 8 mice. P values were determined by Mann-Whitney U test. C) Time courses showing numbers of total splenocytes (i), CD4⁺ T cells (ii), and CD8⁺ T cells (iii) in the spleens from DR3^WT and DR3^KO mice following rVV challenge. DR3^WT receiving PBS (●) or rVV (▲); DR3^KO receiving PBS (○) or rVV (). Each data point represents mean ± se from n ≥ 6 mice. * P < 0.05 at indicated time points; Student’s t test. D) Relative expansion of CD4⁺ and CD8⁺ T cells compared to unchallenged controls following rVV challenge at d 8. Bars show means ± se from n ≥ 6 mice. P values were determined by Mann-Whitney U test.